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Specifications
- Antibody type:Primary
- Antigen name:Zyxin
- Clonality:Monoclonal
- Clone:4D7E7
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human,Mouse
- Antigen symbol:ZYX
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:150 µL
- Western blot:Yes
- Antigen synonyms:ZYX|ESP-2|HED-2
- Storage buffer:PBS with 0.0.2% sodium azide and 50% glycerol pH 7.3.
- Shipping temperature:Store at -20°C
- Immunogen:Fusion Protein
- Purification:Protein G Purification
- Cat. no.:10097-412
- Supplier No.:60254-1-IG
Specifications
About this item
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin (ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.
Western Blot: HeLa Cells, 1:500-1:5000; IHC: Human Kidney Tissue, 1:20-1:200; IF: HeLa Cells, 1:20-1:200
Type: Primary
Antigen: ZYX
Clonality: Monoclonal
Clone: 4D7E7
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse