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Specifications
- Antibody type:Primary
- Antigen name:Zinc Finger, CCHC Domain Containing 11
- Clonality:Polyclonal
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:ZCCHC11
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:150 µL
- Western blot:Yes
- Antigen synonyms:6030404K05Rik|Zinc finger CCHC domain containing 11|KIAA0191|PPAPD3|mKIAA0191|zinc finger CCHC domain-containing protein 11|9230115F04Rik|RP23-406B13.1|TUTase 4|terminal uridylyltransferase 4
- Storage buffer:PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
- Shipping temperature:Store at -20°C
- Immunogen:Fusion Protein
- Purification:Antigen affinity Purification
- Supplier No.:20119-1-AP
Specifications
About this item
ZCCHC11, also named as KIAA0191 and TUT4, is an uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. ZCCHC11 can’t bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28 and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP.
Western Blot: HeLa Cells, 1:200-1:2000; IHC: Human Brain, 1:20-1:200; IF: Hela, 1:10-1:100
Type: Primary
Antigen: ZCCHC11
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human