Anti-MOG Rabbit Polyclonal Antibody

Catalog #: 10090-348

Catalog #: 10090-348

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Specifications

Antibody type:
Primary
Antigen name:
Myelin Oligodendrocyte Glycoprotein
Clonality:
Polyclonal
Host:
Rabbit
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Antigen symbol:
MOG
Conjugation:
Unconjugated
ELISA:
Yes
Size:
150 µL
Western blot:
Yes
Antigen synonyms:
BTNL11|NRCLP7|MOGIG2|BTN6
Storage buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Shipping temperature:
Store at -20°C
Immunogen:
Recombinant Protein
Purification:
Antigen affinity Purification
Cat. no.:
10090-348
Supplier No.:
12690-1-AP

Specifications

About this item

Myelin/oligodendrocyte glycoprotein (MOG), a 26-to 28-kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.