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Specifications
- Antibody type:Primary
- Antigen name:Protein interacting with C kinase 1
- Clonality:Polyclonal
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:PICK1
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:150 µL
- Western blot:Yes
- Antigen synonyms:PRKCABP|PRKCA-binding protein|PICK1|Protein interacting with C kinase 1|PICK|Protein kinase C-alpha-binding protein
- Storage buffer:PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
- Shipping temperature:Store at -20°C
- Immunogen:Recombinant Protein
- Purification:Antigen affinity Purification
- Cat. no.:10092-240
- Supplier No.:10983-2-AP
Specifications
About this item
Protein interacting with C kinase 1 (PICK1) was first cloned as a PKC-binding partner through yeast two hybrid system. PICK1 acts as a critical regulator of membrane receptors’ subcellular trafficking to modulate neural processes such as learning and memory, and is widely expressed in brain, testis, heart, lung, liver, kidney and muscle. It probably binds to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence, for instance, PICK1 is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses. PICK1 expression on D-serine release and glutamate transport in astrocytes suggests a potential implication of PICK1 in the progression of amyotrophic lateral sclerosis (ALS). PICK1 may also participate in breast cancer development through inhibition of TGF-β signaling.
Western Blot: Mouse Brain Tissue, 1:200-1:2000; IHC: Human Prostate Cancer Tissue, 1:20-1:200
Type: Primary
Antigen: PICK1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat