Anti-APEX1 Rabbit Polyclonal Antibody

Catalog #: 10082-084

Supplier: Proteintech

Anti-APEX1 Rabbit Polyclonal Antibody

Catalog #: 10082-084

Supplier: Proteintech

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Specifications

Antibody type:
Primary
Antigen name:
APEX Nuclease (Multifunctional DNA Repair Enzyme) 1
Clonality:
Polyclonal
Host:
Rabbit
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Antigen symbol:
APEX1
Conjugation:
Unconjugated
ELISA:
Yes
ImmunoChemistry:
Yes
Size:
150 µL
Western blot:
Yes
Antigen synonyms:
Protein REF-1|APEX|DNA-(apurinic or apyrimidinic site) lyase|APEN|REF1|APE|APEX nuclease|APX|AP endonuclease 1|Apurinic-apyrimidinic endonuclease 1|APEX1|HAP1
Storage buffer:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping temperature:
Store at -20°C
Immunogen:
Recombinant Protein
Purification:
Antigen affinity Purification
Cat. no.:
10082-084
Supplier No.:
10323-1-AP

Specifications

About this item

APEX1, also named as APE, APE1, HAP1 and REF-1, belongs to the DNA repair enzymes AP/ExoA family. It is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are in DNA repair and redox regulation of transcriptional factors. APEX nuclease is a DNA repair enzyme having apurinic/apyrimidinic (AP) endonuclease, 3-prime,5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. APEX1 is involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). When acetylated at Lys-6 and Lys-7, APEX1 stimulates the YBX1-mediated MDR1 promoter activity, leading to drug resistance. It also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. It plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, APEX1 plays a role in the rRNA quality control process during cell cycle progression. 10323-1-AP is a rabbit polyclonal antibody raised against a fusion protein corresponding to an internal region of human APEX1.