LiChrospher® is Merck's reliable and versatile traditionally produced spherical silica.

LiChrospher® is available with different modifications: LiChrospher® Si 60 and Si 100 are versatile HPLC spherical silica sorbents for normal phase chromatography. LiChrospher® CN has polar and hydrophobic properties, thus can be used as a less polar alternative to LiChrospher® Si 60 in normal phase applications or as a less hydrophobic alternative to LiChrospher® RP-8 in reversed phase applications. In addition, the possibility of selective charged interactions makes it even more versatile. LiChrospher® NH₂ possesses polar and hydrophobic properties and can be used for normal phase, reversed phase and ion exchange chromatography.

Typical applications are the separations of carbohydrates by reversed phase chromatography or the separation of nucleotides by ion exhange chromatography. LiChrospher® DIOL has polar and hydrophobic properties, thus can be used as a less polar alternative to LiChrospher® Si 60 in normal phase applications or as a less hydrophobic alternative to LiChrospher® RP-8 in reversed phase applications. LiChrospher® DIOL is also suitable for exclusion chromatography. LiChrospher® RP-select B is a highly reproducible traditionally produced spherical silica gel with reversed phase properties. This sorbent is very well suited for the separation of basic compounds but can also be used with neutral and acidic samples.

LiChrospher® RP-8, RP-18 and RP-18 endcapped are highly reproducible and versatile traditionally produced spherical silica gel sorbents with reversed phase properties. They are well suited for the separation of neutral, acidic and weak basic compounds. LiChrospher® WP 300 RP-18 is a highly selective and reliable HPLC column for the separation of peptides and low molecular weight proteins. LiChrospher® WP 300 RP-18 enables the tailing-free separation of basic compounds and is ideally suited for the separation of tRNA. LiChrospher® PAH is a highly efficient and selective HPLC column especially designed for the high resolution separation of 16 PAH (polycyclic aromatic hydrocarbons) according to EPA 610 and 550, plus benzo(e)pyrene and perylene.