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Specifications
- Antibody type:Primary
- Antigen name:Interleukin 17 Receptor A
- Clonality:Monoclonal
- Clone:A7R34
- Gene ID:16172
- Host:Rat
- Isotype:IgG2a
- Neutralisation:Yes
- Reactivity:Mouse
- Antigen symbol:IL17RA
- Conjugation:Unconjugated
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:100 µg
- Antigen synonyms:IL-17 R|IL-17 RA|Il17r|AW538159|Cdw217|VDw217
- Storage temperature:Store undiluted at 2-8°C, protect from light, do not freeze.
- Tested applications:Flow Cytometry
- Cat. no.:10051-710
- Supplier No.:70-1271-U100
Specifications
About this item
The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.
The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).
Type: Primary
Antigen: IL17RA
Clonality: Monoclonal
Clone: A7R34
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Mouse