About this item
The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).
The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.
Type: Primary
Antigen: KLRG1
Clonality: Monoclonal
Clone: 2F1
Conjugation: PE (Phycoerythrin)
Epitope:
Host: Golden Syrian Hamster
Isotype: IgG
Reactivity: Mouse
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Specifications
- Catalog No:
- 10051-354
- 10051-356
- Antigen name:
- Killer cell lectin-like receptor subfamily G member 1
- Killer cell lectin-like receptor subfamily G member 1
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- 2F1
- 2F1
- Host:
- Golden syrian hamster
- Golden syrian hamster
- Gene ID:
- 50928
- 50928
- Isotype:
- IgG
- IgG