About this item
The OKT8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
The OKT8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. If used together with alternative antibodies Anti-Human CD8a clone RPA-T8 or Anti-Human CD8a clone Hit8a, the OKT8 antibody will not block binding of RPA-T8 or Hit8a.
Type: Primary
Antigen: CD8A
Clonality:
Clone: OKT8
Conjugation: violetFluor® 450
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity:
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Specifications
- Catalog No:
- 10051-780
- 10051-782
- Antigen name:
- CD8 antigen, alpha chain
- CD8 antigen, alpha chain
- Antibody type:
- Primary
- Primary
- Clone:
- OKT8
- OKT8
- Host:
- Mouse
- Mouse
- Gene ID:
- 925
- 925
- Isotype:
- IgG2a
- IgG2a
- Neutralisation:
- Yes
- Yes
Specifications
Related Information
tds-75-0086.pdf
Datasheet
Tonbo Biosciences violetFluor™ Antibodies.pdf