About this item
The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247).
The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
Type: Primary
Antigen: KLRB1C
Clonality: Monoclonal
Clone: PK136
Conjugation: PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Mouse
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Specifications
- Catalog No:
- 10051-618
- 10051-616
- Antigen symbol:
- KLRB1C
- KLRB1C
- Antigen name:
- Killer Cell Lectin-Like Receptor Subfamily B, Member 1
- Killer Cell Lectin-Like Receptor Subfamily B, Member 1
- Antigen synonyms:
- NK-RP1|ly-55c|Nk1|AI462337|NKR-P1.9|Ly-59|Nk-1.2|NK1.1|Ly55c|Ly59|Nk-1|Nkrp1c|NKRP140|CD161|Nk1.2|NKRP1
- NK-RP1|ly-55c|Nk1|AI462337|NKR-P1.9|Ly-59|Nk-1.2|NK1.1|Ly55c|Ly59|Nk-1|Nkrp1c|NKRP140|CD161|Nk1.2|NKRP1
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®
- PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®
- Clone:
- PK136
- PK136
- Reactivity:
- Mouse
- Mouse
- Host:
- Mouse
- Mouse
- Gene ID:
- 17059
- 17059
- Isotype:
- IgG2a
- IgG2a
- Flow cytometry:
- Yes
- Yes
- Neutralisation:
- Yes
- Yes
- Storage temperature:
- Store Undiluted at 2 to 8°C; Protect from Light; Do Not Freeze.
- Store Undiluted at 2 to 8°C; Protect from Light; Do Not Freeze.
- Tested applications:
- Flow Cytometry
- Flow Cytometry
Specifications
Supplier: VWR International
Supplier: BDH
Supplier: VWR International
Supplier: VWR International
Supplier: VWR International
Supplier: Corning