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Specifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Mouse
- Size:0.01 mg
- Biological activity:Endotoxin level is less than 0.1 ng per μg (1EU/μg).
- Protein synonyms:OS5|GDF-5|SYNS2|Cartilage-derived morphogenetic protein 1|BDA1C|LAP4|CDMP1|SYM1B|BMP14
- Protein/peptide name:GDF5
- Purity:>98%
- Formulation:Lyophilized
- Cat. no.:10073-062
- Supplier No.:40-579
Specifications
About this item
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.