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Specifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.005 mg
- Biological activity:Biological activity was determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
- Protein synonyms:ARMETL1|ARMET-like protein 1|Cerebral dopamine neurotrophic factor
- Protein/peptide name:Cdnf
- Purity:>98%
- Formulation:Lyophilized
- Cat. no.:10073-016
- Supplier No.:40-550
Specifications
About this item
CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.