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Specifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.01 mg
- Biological activity:Determined by its ability to chemoattract human peripheral blood lymphocytes using a concentration range of 50.0-1000.0 ng/mL.
- Protein synonyms:NIL16|Lymphocyte chemoattractant factor|prIL-16|IL-16|PRIL16|Pro-interleukin-16|LCF
- Protein/peptide name:IL16
- Purity:>98%
- Formulation:Lyophilized
- Tested applications:Western Blot, ELISA
- Cat. no.:10070-558
- Supplier No.:40-597
Specifications
About this item
IL-16 was initially identified as a chemotactic cytokine (1), but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases (2). The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20 kDa active form that binds to and signals through CD4 (3,4). Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation (5) and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders (6). At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus (7). This recombinant protein fragment is derrived from this longer isoform.
This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
1X PBS containing 0.1% SDS
Store in working aliquots at -80°C. Avoid freeze/thaw cycles.