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Specifications
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Human
- Size:0.01 mg
- Biological activity:ICAM - 1 supported the adhesion of more than 50% PMA - stimulated HSB2 cells to plates coated at 25 ng/mL ICAM - 1 concentration
- Protein synonyms:ICAM-1|BB2|Intercellular adhesion molecule 1|CD54|Major group rhinovirus receptor|P3.58
- Protein/peptide name:ICAM1
- Purity:>98%
- Formulation:Lyophilized
- Cat. no.:10072-812
- Supplier No.:40-238
Specifications
About this item
ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain. Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.