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Specifications
- Gene ID:8190
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.005 mg
- Biological activity:The ED50 was determined by the dose - dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4 - 6 μg/mL.
- Protein synonyms:CD-RAP|Melanoma inhibitory activity protein|Melanoma-derived growth regulatory protein
- Protein/peptide name:MIA
- Purity:>98%
- Formulation:Lyophilized
- Cat. no.:10072-788
- Supplier No.:40-226
Specifications
About this item
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.