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Specifications
- Protein/peptide type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:0.002 mg
- Protein synonyms:c-Fos-induced growth factor|VEGF-D|VEGFD|Vascular endothelial growth factor D
- Protein/peptide name:VEGFD
- Purity:>95%
- Formulation:Lyophilized
- Cat. no.:10072-700
- Supplier No.:40-166
Specifications
About this item
VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.