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Specifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.005 mg
- Biological activity:Biological activity was determined by its ability to inhibit TWEAK - induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0 - 3.0 μg/mL.
- Protein synonyms:FGF-inducible 14|CD266|FN14|Fibroblast growth factor-inducible immediate-early response protein 14|TWEAKR|Tumor necrosis factor receptor superfamily member 12A
- Protein/peptide name:TWEAK Receptor
- Purity:>98%
- Formulation:Lyophilized
- Cat. no.:10072-918
- Supplier No.:40-312
Specifications
About this item
TWEAKR belongs to the TNF family of transmembrane proteins and contains a cytoplasmic "death domain", which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.