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Specifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.01 mg
- Biological activity:Biological activity was determined by its inhibitory effect of IL - 8 production in human PBMC by human sTRAIL/Apo2L. 95% inhibition (100 ng/mL of s TRAIL/Apo2L) was reached using a concentration of 100 ng/mL of sTRAIL Receptor - 1.
- Protein synonyms:Death receptor 4|TRAILR1|DR4|Tumor necrosis factor receptor superfamily member 10A|TRAIL receptor 1|APO2|CD261|TRAILR-1
- Protein/peptide name:TRAILR1 (soluble)
- Purity:>98%
- Formulation:Lyophilized
- Cat. no.:10072-912
- Supplier No.:40-309
Specifications
About this item
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.