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Specifications
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Size:0.05 mg
- Protein synonyms:26S protease regulatory subunit 10B|SUG2|P44|26S proteasome AAA-ATPase subunit RPT4|p42|CADP44|HEL-S-73
- Protein/peptide name:Psmc6
- Purity:>95%
- Molecular weight:44.7 kDa (Calculated)
- Tested applications:ELISA, Western Blot, MS
- Cat. no.:10072-338
- Supplier No.:XW-RP3212
Specifications
About this item
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 α subunits and 2 rings are composed of 7 β subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
This recombinant protein can be used for WB, ELISA, MS.
10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN, 10mM DTT
Store in working aliquots at -80°C. Avoid freeze/thaw cycles.