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Specifications
- Antibody type:Primary
- Antigen name:interleukin 11
- Clonality:Polyclonal
- Gene ID:P20809
- Host:Rabbit
- Neutralisation:Yes
- Reactivity:Human
- Antigen symbol:IL11
- Conjugation:Unconjugated
- ELISA:Yes
- Size:0.1 mg
- Western blot:Yes
- Form:Lyophilized
- Antigen synonyms:IL11
- Shipping temperature:RT
- Immunogen:Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIL-11 (human Interleukin-11).
- Purification:Anti-hIL-11 specific antibody was purified by affinity chromatography employing immobilized hIL-11 matrix.
- Cat. no.:10098-530
- Supplier No.:XP-5164
Specifications
About this item
Interleukin 11 is a pleiotropic cytokine produced by mesenchymal-derived adherent cells. IL11 shares many functions of IL6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation, and enhancement of hepatic acute phase protein production. Interleukin 11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.
Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hIL-11 (1.50 ng/mL), a concentration of 0.02 - 0.05 µg/mL of this antibody is required. ELISA: To detect hIL-11 by direct ELISA (using 100 µL/well antibody solution) a concentration of at least 0.5 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2 - 0.4 ng/well of recombinant hIL-11. Sandwich: To detect hIL-11 by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5 - 2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with our Biotinylated Anti-Human IL-11 (XP-5164Bt) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hIL-11. Western Blot: To detect hIL-11 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hIL-11 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
Anti-hIL-11 specific antibody was purified by affinity chromatography employing immobilized hIL-11 matrix.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: IL11
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human