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Specifications
- Antibody type:Primary
- Antigen name:gap junction protein, alpha 1
- Clonality:Polyclonal
- Gene ID:P08050
- Host:Rabbit
- Reactivity:Zebrafish,Goat,Chicken,Human,Bovine,Dog,Rat,Mouse
- Antigen symbol:Gja1
- Conjugation:Unconjugated
- Size:0.1 mL
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:Gja1
- Modification:Ser 368
- Storage buffer:100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
- Molecular weight:43
- Storage temperature:Connexin 43 antibody can be stored at –20 °C and is stable at –20 °C for at least 1 year.
- Shipping temperature:4 °C
- Immunogen:Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat connexin 43.
- Purification:Affinity Purified
- Cat. no.:10075-462
- Supplier No.:50-220
Specifications
About this item
Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin 43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin 43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002; Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin 43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, guinea pig, human, mouse and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Affinity Purified
100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: Gja1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat, Dog, Zebrafish, Goat, Bovine, Chicken