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Specifications
- Antibody type:Primary
- Antigen name:thyroid hormone receptor, alpha
- Clonality:Monoclonal
- Clone:2103
- Gene ID:P10827
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human,Dog,Rat,Mouse
- Antigen symbol:THRA
- Conjugation:Unconjugated
- Size:0.1 mL
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:THRA
- Storage buffer:100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
- Molecular weight:50/58
- Storage temperature:Thyroid Hormone Receptor antibody can be stored at –20 °C and is stable at –20 °C for at least 1 year.
- Shipping temperature:4 °C
- Immunogen:Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a1/a2-isotype.
- Purification:Protein G purified
- Cat. no.:10075-396
- Supplier No.:50-170
Specifications
About this item
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with canine, mouse and rat based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Protein G purified
100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: THRA
Clonality: Monoclonal
Clone: 2103
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse, Rat, Dog