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Specifications
- Antibody type:Primary
- Antigen name:CREB regulated transcription coactivator 1
- Clonality:Polyclonal
- Gene ID:Q6UUV9
- Host:Rabbit
- Reactivity:Zebrafish,Pufferfish,Human,Bovine,Rat,Mouse
- Antigen symbol:CRTC1
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:0.05 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:CRTC1
- Storage buffer:0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
- Storage temperature:Short term: 4 °C. Long term: Store at –20 °C. Avoid freeze-thaw cycles.
- Concentration:0.95 mg/mL
- Shipping temperature:4 °C
- Immunogen:CRTC1 antibody was raised against amino acids 19 - 34 of CRTC1 (Human).
- Tested applications:Immunoaffinity Chromatography
- Purification:Immunoaffinity Chromatography
- Cat. no.:10078-902
- Supplier No.:49-411
Specifications
About this item
MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response element-binding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.
CRTC1 antibody can be used in ELISA starting at 1:14000 - 1:80000, Western Blot starting at 1:100 - 1:8000, immunohistochemistry starting at 5 ?g/mL, and immunofluorescence.
0.02 M potassium phosphate, 0.15 M NaCl, pH 7.2, 0.01% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: CRTC1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Bovine, Human, Mouse, Pufferfish, Rat, Zebrafish