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Specifications
- Antibody type:Primary
- Antigen name:tumor necrosis factor receptor superfamily, member 13B
- Clonality:Polyclonal
- Gene ID:O14836
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Mouse
- Antigen symbol:TNFRSF13B
- Conjugation:Unconjugated
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- Size:0.05 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:TNFRSF13B
- Storage buffer:PBS containing 0.05% sodium azide
- Storage temperature:TNFRSF13B antibody can be stored short term 4 °C. For long term storage aliquot and store at –20 °C. As with all antibodies avoid freeze/thaw cycles.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:TNFRSF13B antibody was raised against amino acids 116 - 132 of TNFRSF13B (Human).
- Tested applications:Fluorescence-Activated Cell Sorting
- Purification:Protein G Column
- Cat. no.:10078-816
- Supplier No.:49-347
Specifications
About this item
Simultaneously four different laboratories identified a a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and BlyS (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The receptor for BlyS/BAFF appears to be expressed predominantly on B cells and activated T cells. Recently two orphan receptors TACI and BCMA (,8) have been shown to be receptors for BlyS/BAFF (6-9). TACI is expressed on B cells and signals through CAML, activating the transcription factors NF-AT, NF-κB, and AP-1. TACI is one of three know receptors for BLys. Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-κB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
TNFRSF13B antibody can be used in Western Blot starting at 1:1000, immunohistochemistry starting at 5 ?g/mL, immunohistochemistry -Pfa starting at 1 ?g/mL, and flow cytometry.
Protein G Column
PBS containing 0.05% sodium azide and 0.2% gelatin.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: TNFRSF13B
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse