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Specifications
- Antibody type:Primary
- Antigen name:T-cell leukemia homeobox 1
- Clonality:Polyclonal
- Gene ID:P31314
- Host:Rabbit
- Isotype:IgG
- Reactivity:Rat,Mouse,Hamster,Bat,Rabbit,Horse,Monkey,Gibbon,Gorilla,Chicken,Human,Bovine,Dog
- Antigen symbol:TLX1
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:0.05 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:TLX1
- Storage buffer:PBS, 0.2% gelatin, 0.05% sodium azide.
- Storage temperature:TLX1 antibody can be stored short term 4 °C. For long term storage aliquot and store at –20 °C. As with all antibodies avoid freeze/thaw cycles.
- Concentration:0.5 mg/mL
- Shipping temperature:4 °C
- Immunogen:TLX1 antibody was raised against amino acids 300 - 330 of TLX1 (Human).
- Purification:Protein G Column
- Cat. no.:10076-348
- Supplier No.:49-322
Specifications
About this item
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
TLX1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 ?g/mL, and immunofluorescence starting at 10 ?g/mL.
Protein G Column
PBS, 0.2% gelatin, 0.05% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: TLX1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat