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Specifications
- Antibody type:Primary
- Antigen name:RAD54-like
- Clonality:Monoclonal
- Clone:[60.1]
- Gene ID:Q92698
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:RAD54L
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:0.05 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:RAD54L
- Storage buffer:PBS, pH 7.2. No preservatives added.
- Storage temperature:Short term: 4 °C. Long term: Store at –20 °C. Avoid freeze-thaw cycles.
- Concentration:1 mg/mL
- Shipping temperature:-20 °C
- Immunogen:RAD54L monoclonal antibody was raised against a combination of N & C peptide, corresponding to a range between amino acids 1-300 and 450-741
- Purification:Protein G Column
- Cat. no.:10078-376
- Supplier No.:48-838
Specifications
About this item
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
ATRX antibody can be used in ELISA, and immunohistochemistry starting at 10 ?g/mL.
Protein G Column
PBS, pH 7.2. No preservatives added.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: RAD54L
Clonality: Monoclonal
Clone: [60.1]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human