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Specifications
- Antibody type:Primary
- Antigen name:lysine (K)-specific methyltransferase 2A
- Clonality:Monoclonal
- Clone:10F8D7
- Gene ID:Q03164
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:KMT2A
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:0.1 mL
- Western blot:Yes
- Antigen synonyms:KMT2A
- Storage buffer:Ascitic fluid containing 0.03% sodium azide.
- Storage temperature:MLL monoclonal antibody can be stored at –20 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping temperature:4 °C
- Immunogen:Purified truncated recombinant MLL-Trx (aa3751-3968) is expressed in E.Coli strain BL21 (DE3).
- Cat. no.:10070-626
- Supplier No.:32-194
Specifications
About this item
Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila).Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle,that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN)
functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia,also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Ascitic fluid containing 0.03% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: KMT2A
Clonality: Monoclonal
Clone: 10F8D7
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human