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Specifications
- Antibody type:Primary
- Antigen name:B-cell CLL/lymphoma 10
- Clonality:Monoclonal
- Clone:4F8E8H8
- Gene ID:O95999
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:BCL10
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:0.1 mg
- Western blot:Yes
- Antigen synonyms:BCL10
- Storage temperature:BCL-10 monoclonal antibody can be stored at –20 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping temperature:4 °C
- Immunogen:Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3).
- Purification:Antibody is purified by protein A affinity chromatography.
- Cat. no.:10073-178
- Supplier No.:32-115
Specifications
About this item
B-cell CLL/lymphoma 10, also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-κB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-κB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-κB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
IHC(P):Dilution 1:1,000 - 1:2,000 IHC(F):Dilution 1:1,000 - 1:2,000 Western blot:Dilution 1:2,000 - 1:5,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Antibody is purified by protein A affinity chromatography.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: BCL10
Clonality: Monoclonal
Clone: 4F8E8H8
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human