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Specifications
- Antibody type:Primary
- Antigen name:ATG13 autophagy related 13 homolog (S. cerevisiae)
- Clonality:Polyclonal
- Gene ID:O75143
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:ATG13
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:0.1 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:ATG13
- Storage buffer:ATG13 Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular weight:Predicted: 44, 53, 57, 61 kDa Observed: 49 kDa
- Storage temperature:ATG13 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:ATG13 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATG13. The immunogen is located within amino acids 450 - 500 of ATG13.
- Tested applications:E, WB, IHC, IF
- Purification:ATG13 Antibody is affinity chromatography purified via peptide column.
- Cat. no.:89417-488
- Supplier No.:5799
Specifications
About this item
ATG13 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
Type: Primary
Antigen: ATG13
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat