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Specifications
- Antibody type:Primary
- Antigen name:zinc finger, FYVE domain containing 26
- Clonality:Polyclonal
- Gene ID:Q68DK2
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:ZFYVE26
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoFluorescence:Yes
- Size:0.1 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:ZFYVE26
- Storage buffer:SPG15 Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular weight:Predicted: 280 kDa Observed: 260 kDa
- Storage temperature:SPG15 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15. The immunogen is located within amino acids 1710 - 1760 of SPG15.
- Tested applications:E, WB, IF
- Purification:SPG15 Antibody is affinity chromatography purified via peptide column.
- Cat. no.:89416-898
- Supplier No.:5023
Specifications
About this item
SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.
Type: Primary
Antigen: ZFYVE26
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat