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Specifications
- Antibody type:Primary
- Antigen name:chromosome 12 open reading frame 5
- Clonality:Polyclonal
- Gene ID:Q9NQ88
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Antigen symbol:C12orf5
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:0.1 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:C12orf5
- Storage buffer:TIGAR Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage temperature:TIGAR antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:TIGAR antibody was raised against a 18 amino acid synthetic peptide from near the center of human TIGAR. The immunogen is located within amino acids 60 - 110 of TIGAR.
- Tested applications:E, WB, IHC
- Purification:TIGAR Antibody is affinity chromatography purified via peptide column.
- Cat. no.:89416-210
- Supplier No.:4049
Specifications
About this item
TIGAR Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.
Type: Primary
Antigen: C12orf5
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat