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Specifications
- Antibody type:Primary
- Antigen name:baculoviral IAP repeat-containing 2
- Clonality:Polyclonal
- Gene ID:Q13490
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human,Mouse
- Antigen symbol:BIRC2
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:0.1 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:BIRC2
- Storage buffer:cIAP Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage temperature:cIAP antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:c-IAP antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human c-IAP1 c-IAP antibody detects both c-IAP1 and c-IAP2. The immunogen is located within amino acids 540 - 590 of cIAP.
- Tested applications:E, WB, IHC, IF
- Purification:cIAP Antibody is affinity chromatography purified via peptide column.
- Cat. no.:89415-690
- Supplier No.:3325
Specifications
About this item
cIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-alpha by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.
Type: Primary
Antigen: BIRC2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse