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Specifications
- Antibody type:Primary
- Antigen name:DNA fragmentation factor, alpha subunit
- Clonality:Polyclonal
- Gene ID:O54786
- Host:Rabbit
- Isotype:IgG
- Reactivity:Mouse
- Antigen symbol:Dffa
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:0.1 mg
- Western blot:Yes
- Form:Liquid
- Antigen synonyms:Dffa
- Storage buffer:ICAD Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular weight:45 kDa
- Storage temperature:ICAD antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping temperature:4 °C
- Immunogen:ICAD antibody was raised against a peptide corresponding to amino acids near the amino terminus of mouse ICAD. The immunogen is located within the first 50 amino acids of ICAD.
- Tested applications:E, WB, IHC, IF
- Purification:ICAD Antibody is affinity chromatography purified via peptide column.
- Cat. no.:89415-268
- Supplier No.:2001
Specifications
About this item
ICAD Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which is cleaved by caspase-3 during apoptosis. Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD, for inhibitor of caspase-activated DNase. Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei. Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is the hallmark of apoptotic cell death.
Type: Primary
Antigen: Dffa
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse