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Human Recombinant ABL1, HIS Tag, Enzo Life Sciences
Human Recombinant ABL1, HIS Tag, Enzo Life Sciences
Catalog #: 89164-538
Supplier:  Enzo Life Sciences
CAS Number:  
Abl1 (Human), (Rec.) (His-Tag) 5 ug
Human Recombinant ABL1, HIS Tag, Enzo Life Sciences
Catalog #: 89164-538
Supplier:  Enzo Life Sciences
CAS Number:  
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Specifications

  • Protein/peptide type:
    Recombinant
  • Species:
    Human
  • Size:
    5 µg
  • Tag sequence:
    HIS Tag
  • Biological activity:
    871 nmol/min/mg using a peptide substrate, EAIYAAPFAKKK, in 25mM MOPS, pH 7.2, containing 12.5mM β-glycerol-phosphate, 25mM MgCl2, 5mM EGTA, 2mM EDTA. Add 0.25mM DTT to assay buffer prior to use.
  • Protein/peptide name:
    ABL1
  • Purity:
    >70% (SDS-PAGE)
  • Concentration:
    0.1mg/ml
  • Formulation:
    Liquid. In 50mM TRIS-HCl, pH 7.5, containing 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
  • Cat. no.:
    89164-538
  • Supplier No.:
    SE562-0005

Specifications

About this item

Produced in insect cells.

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. The c-Abl protein is inhibited by its SH3 domain, and deletion of this domain turns ABL1 into an oncogene. A chromosomal translocation results in the head-to-tail fusion of the BCR and ABL1 genes. This translocation is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of Abl1 is regulated by CDC2-mediated phosphorylation.

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