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Specifications
- Protein/peptide type:Recombinant
- Species:Human
- Size:5 µg
- Tag sequence:HIS Tag
- Biological activity:871 nmol/min/mg using a peptide substrate, EAIYAAPFAKKK, in 25mM MOPS, pH 7.2, containing 12.5mM β-glycerol-phosphate, 25mM MgCl2, 5mM EGTA, 2mM EDTA. Add 0.25mM DTT to assay buffer prior to use.
- Protein/peptide name:ABL1
- Purity:>70% (SDS-PAGE)
- Concentration:0.1mg/ml
- Formulation:Liquid. In 50mM TRIS-HCl, pH 7.5, containing 150mM sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF and 25% glycerol.
- Cat. no.:89164-538
- Supplier No.:SE562-0005
Specifications
About this item
Produced in insect cells.
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. The c-Abl protein is inhibited by its SH3 domain, and deletion of this domain turns ABL1 into an oncogene. A chromosomal translocation results in the head-to-tail fusion of the BCR and ABL1 genes. This translocation is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of Abl1 is regulated by CDC2-mediated phosphorylation.