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Specifications
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Mouse
- Size:10 µg
- Endotoxin content:\<0.1EU/µg purified protein (LAL test; Bio Whittaker).
- Biological activity:Binds to mouse and human CD40. Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86).
- Reconstitution instructions:Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
- Protein/peptide name:MegaCD40L™ (soluble)
- Purity:>95% (SDS-PAGE)
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS.
- Cat. no.:89151-916
- Supplier No.:522-120-C010
Specifications
About this item
Highly active. Produced in CHO cells. The extracellular domain of mouse CD40L (CD154) (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.
MegaCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30/adiponectin. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations (Prod. No. ALX-850-075).