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Specifications
- Antibody type:Primary
- Antigen name:Caspase 7
- Clonality:Monoclonal
- Host:Mouse
- Isotype:IgG2b
- Reactivity:Human
- Antigen symbol:CASP7
- ImmunoChemistry:Yes
- Size:100 µg
- Western blot:Yes
- Antigen synonyms:Caspase 7 Apoptosis-related Cysteine Peptidase|CASP-7|MCH3|CASP7|ICE-LAP3|CMH-1
- Cat. no.:CA200061-504
- Supplier No.:AAM-127E
Specifications
About this item
The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
- For Immunohistochemistry, Western Blot
Recognizes human, mouse, rat, dog, hamster, monkey, pig, rabbit and sheep Caspase-7. Detects the unprocessed pro-caspase-7 (p35), caspase lacking the short amino-terminal pro-domain (p32) and fully processed caspase-7 (p19) in the apototic cell extract.
Type: Primary
Antigen: CASP7
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype:
Reactivity: Human