To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.
Specifications
- Antibody type:Primary
- Antigen name:Adrenoceptor Beta 1
- Clonality:Polyclonal
- Host:Rabbit
- Reactivity:Rat
- Antigen symbol:ADRB1
- ELISA:Yes
- Size:100 µg
- Western blot:Yes
- Form:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
- Antigen synonyms:RHR|BETA1AR|B1AR|ADRB1R|adrenoceptor beta 1
- Purification:Peptide affinity purified
- Cat. no.:89141-434
- Supplier No.:905-784-100
Specifications
About this item
Adrenergic receptors mediate the hormone and neurotransmitter functions of adrenaline and noradrenaline. Adrenoreceptors function in peripheral tissues and the central nervous system to regulate numerous vascular, metabolic, and neurological functions, and are the target for many therapeutically relevant drugs including those for the treatment of hypertension, asthma, benign prostatic hypertrophy, and depression. Adrenoreceptors are classified by three types (α1, α2, and β) and multiple subclasses based on pharmacological and molecular characteristics. The three β adrenergic receptor subtypes (β 1, 2, 3) signal primarily via coupling to GS alpha subunits, stimulating production of cAMP and activation of protein kinase A to regulate opening of L-type Ca2+ channels. Expression of β1 receptors is highest in the heart and in adipose tissue, displaying relatively equal sensitivity to adrenaline and noradrenaline. The β 2 receptor mediates relaxation in vascular, uterine, and pulmonary smooth muscle, and shows greater sensitivity to noradrenaline compared to adrenaline. Agonist affinity to β2 adrenergic receptors is modulated by Zn2+ concentration, and may also trigger cGMP accumulation and protein kinase G activation via Gi/o alpha subunit coupling in some cell types.
- For ELISA, Flow Cytometry, Western Blot
Recognizes rat adrenergic receptor beta1. Predicted MW of ~50kDa. Higher MW species (~75kDa) and intermediates also observed by Western blot which reflect post-translational modification and dimerization of the receptor. Predicted species reactivity based on epitope sequence homology: human, mouse, guinea pig, wild boar, chimpanzee, dog, cat, rhesus macaque, bovine, opossum.
Type: Primary
Antigen: ADRB1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Rat