Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)
Supplier: Bachem Americas
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See also the Asp derivatives N-1425 and N-1430, and Z-YVAD-FMK (N-1595).
Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE). It bears the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
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