Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH Trifluoroacetate
Catalog #: M-2115.0001BA
Supplier: Bachem Americas
CAS Number:
Specifications
- CAS No.:174838-79-0
- Size:1 mg
- Storage conditions:–20 ± 5 °C
- MDL No.:MFCD18782537
- Protein/peptide name:Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH Trifluoroacetate
- Molecular weight:1241.37
- Sequence:Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-m-nitro-Tyr-Asp-OH
- Molecular formula:C₅₄H₈₄N₁₈O₁₆
- Cat. no.:M-2115.0001BA
- Supplier No.:M-2115.0001
Specifications
About this item
This internally quenched fluorogenic peptide substrate contains anthranilic acid as fluorescent donor and m-nitro-tyrosine as acceptor (quencher). The sequence Abz-RVKRGLAY(NO₂)E is based on the sequence of hemagglutinin. The FRET substrate is efficiently cleaved by furin, a subtilisin-like eukaryotic serine endoprotease with Km = 3.8 µM and kcat = 29.3 s⁻¹ (kcat/Km = 7'710'000 M⁻¹s⁻¹). Its kcat/Km value is over 2000-fold higher than that of the commonly used substrate Boc-Arg-Val-Arg-Arg-AMC (I-1645). FRET Substrate for the basic residue-specific yeast aspartyl protease yapsin 1.
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