Succinyl-(Pro⁵⁸, D-Glu⁶⁵)-Hirudin (56-65) (sulfated)
Catalog #: H-8145.0001BA
Supplier: Bachem Americas
CAS Number:
Specifications
- CAS No.:131791-98-5
- Size:1 mg
- Storage conditions:–20 ± 5 °C
- Protein/peptide name:Succinyl-(Pro⁵⁸,D-Glu⁶⁵)-Hirudin
- Molecular weight:1445.52
- Sequence:Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(SO₃H)-Leu-D-Glu-OH
- Molecular formula:C₆₄H₈₈N₁₀O₂₆S
- Cat. no.:H-8145.0001BA
- Supplier No.:H-8145.0001
Specifications
About this item
These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.
This analog of the C-terminal sequence of hirudin acts as an antithrombotic agent. It inhibits the thrombin-induced fibrin clot formation with an IC₅₀ value of 0.087 µM.
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