Anticoagulant and antithrombotic peptides. Please see also the product family 'Hirudin Fragments and Analogs', the inhibitors N-1065, N-1215, N-1260, N-1565, and N-1970, and the anticoagulant anisindione, Q-1085.

The potent anticoagulant E-76, Acetyl-ALCDDPRVDRWYCQFVEG-amide, is an inhibitor of coagulation factor VIIa. It has been suggested that E-76 works by binding to an exosite on the factor VIIa protease domain, and non-competitively inhibits activation of factor X and amidolytic activity. E-76 has a well defined structure in solution determined by NMR spectroscopy that is similar to the X-ray crystal structure when complexed with factor VIIa and represents a new framework for the development of inhibitors for serine proteases.