Astressin Trifluoroacetate | Proteins and Peptides

Astressin Trifluoroacetate

Supplier: Bachem Americas

Astressin Trifluoroacetate

Supplier: Bachem Americas

About this item

The Glu³⁰ to Lys³³ lactam bridge constrains astressin in an α-helical conformation which seems to be responsible for its especially high CRF antagonist activity. Astressin is 100 times more potent than α-helical CRF (9-41) (H-2040) at inhibiting ACTH secretion in vitro, and more than 10 times more potent in vivo than any other CRF antagonist reported to date.

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