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Specifications
- Antibody type:Primary
- Antigen name:Proteasome (prosome macropain) 26S Subunit ATPase 6
- Clonality:Polyclonal
- Gene ID:5706
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:PSMC6
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:100 μl
- Western blot:Yes
- Antigen synonyms:SUG2|P44|p42|CADP44|HEL-S-73
- Storage buffer:0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
- Molecular weight:44 kDa
- Storage temperature:Keep as concentrated solution. Aliquot and store at –20 °C or below. Avoid multiple freeze-thaw cycles.
- Concentration:0.76 mg/ml
- Immunogen:Recombinant protein encompassing a sequence within the center region of human PSMC6. The exact sequence is proprietary.
- Tested applications:ICC/IF, IHC-P, WB
- Purification:Purified by antigen-affinity chromatography.
- Cat. no.:89358-122
- Supplier No.:GTX114677
Specifications
About this item
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq]
Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Type: Primary
Antigen: PSMC6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human