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Specifications
- Antibody type:Primary
- Antigen name:NKIRAS1
- Clonality:Monoclonal
- Clone:184C278
- Gene ID:13666
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:Eif2ak3
- Conjugation:Unconjugated
- Size:100 μg
- Western blot:Yes
- Amino acid number:96 to 113
- Storage buffer:Preservative: 0.02% Sodium Azide; Constituents: PBS
- Sequence:RVELLKKEIDKFKDKKEV
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.5 mg/ml
- Immunogen:Synthetic peptide: RVELLKKEIDKFKDKKEV, corresponding to amino acids 96-113 of Human NKIRAS1.
- Tested applications:WB
- Purification:Protein G purified
- Cat. no.:89359-806
- Supplier No.:GTX13666
Specifications
About this item
NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified. These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation.
WB: Use at a concentration of 0.5 - 1 ?g/ml. Predicted molecular weight: 23 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: Eif2ak3
Clonality: Monoclonal
Clone: 184C278
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse, Rat