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Specifications
- Antibody type:Primary
- Antigen name:Major Vault Protein
- Clonality:Monoclonal
- Clone:0.N.389
- Gene ID:9961
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:MVP
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:250μl
- Western blot:Yes
- Antigen synonyms:VAULT1|LRP
- Storage buffer:Preservative: 15mM Sodium Azide; Constituents: 0.2% BSA, 10mM PBS, 40% glycerol, pH 7.4
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.1 mg/ml
- Immunogen:Proteins purified from extract of human breast cancer MCF-7 cells.
- Tested applications:IHC-P, IP, WB
- Purification:Protein G purified
- Cat. no.:89360-038
- Supplier No.:GTX14562
Specifications
About this item
Major vault protein (MVP) is identical to lung resistance related protein (LRP). Its shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocortoid receptors are also able to co-immunoprecipitate the MVP. Reportedly, the lung resistance related protein (LRP) is identical to human MVP. LRP is overexpressed in many neoplastic tissues and cells lines indicating a poor response to chemotherapy.
IHC-P: Use at a concentration of 2-4 ?g/ml. IP: Use at a concentration of 2 ?g/ml. WB: Use at a concentration of 1 ?g/ml. Detects a band of approximately 104-110 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: MVP
Clonality: Monoclonal
Clone: 0.N.389
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human