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Specifications
- Antibody type:Primary
- Antigen name:Paraneoplastic Ma Antigen 2
- Clonality:Polyclonal
- Gene ID:10687
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:MA2
- Conjugation:Unconjugated
- Size:200μl
- Western blot:Yes
- Antigen synonyms:RGAG2|MA2|MM2
- Storage buffer:Preservative: 0.02% Sodium Azide; Constituents: PBS, 0.1mg/ml BSA.
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Immunogen:Synthetic peptide: AHLLGQAMAHAPQPLL, corresponding to amino acids 143-158 of Human MA2.
- Tested applications:WB
- Purification:Protein G purified
- Cat. no.:89359-824
- Supplier No.:GTX13705
Specifications
About this item
In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a para-neoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a ""brain-testis-cancer"" gene related to other para-neoplastic syndromes and tumors.
WB: Use at a dilution of 1/500 - 1/1000. Predicted molecular weight: 44 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: MA2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human