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Specifications
- Antibody type:Primary
- Antigen name:Immunoglobulin
- Clonality:Monoclonal
- Clone:7A9
- Host:Mouse
- Isotype:IgG2a
- Reactivity:Human
- Antigen symbol:Ig
- Conjugation:Unconjugated
- ELISA:Yes
- Size:1 mg
- Epitope:Light Chain
- Storage buffer:Phosphate-buffered saline, pH 7.4, containing 0.1% sodium azide
- Storage temperature:Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. We recommend to parafilm vials during storage to prevent evaporation of buffer.
- Immunogen:Mixture of light chains of human immunoglobulin.
- Tested applications:Conjugation
- Purification:Protein A purified
- Cat. no.:89351-682
- Supplier No.:GTX21942
Specifications
About this item
There are only two types of light chain: kappa and lambda in mammals. Other types of light chains are found in lower vertebrates as the Ig-Light-Iota chain in Chondrichthyes and Teleostei. In each antibody, only one type is present and the two chains are identical. Each light chain has two successive domains: one constant and one variable domain.In humans 60% of light chains are kappa and 40% lambda,whereas in the mouse 95% of light chains are kappa. The amino acid sequences of lambda chains vary slightly at a few positions, allowing them to be classified into subtypes. The number of subtypes varies between species.Monoclonal immunoglobulin free light chains (FLC) are found in the serum and urine (Bence-Jones protein) of patients with a number of B-cell proliferative disorders, including multiple myeloma. Changes in serum FLC concentrations can provide a rapid and sensitive indication of response to treatment.
For indirect ELISA: Use at a dilution of 1:1,000,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Type: Secondary
Antigen: Ig
Clonality: Monoclonal
Clone: 7A9
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human