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Specifications
- Antibody type:Primary
- Antigen name:Death Receptor 4
- Clonality:Monoclonal
- Clone:32A1380
- Gene ID:8797
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:DR4
- Conjugation:Unconjugated
- Size:50 μg
- Western blot:Yes
- Antigen synonyms:TRAIL-R1|TRAILR1|cytotoxic TRAIL receptor|TRAIL receptor 1|APO2|death receptor 4|CD261|TRAILR-1
- Amino acid number:1 to 20
- Storage buffer:Preservative: 0.02% Sodium Azide; Constituents: PBS
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.5 mg/ml
- Immunogen:Synthetic peptide, corresponding to amino acids 1 - 20 of Human DR4.
- Tested applications:WB
- Purification:Protein G purified
- Cat. no.:89358-996
- Supplier No.:GTX11931
Specifications
About this item
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified and designated DR4 (for death receptor 4). The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor 1(TRAIL R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF kB activation in many tissues and cells.
WB: Use at a concentration of 2 - 4 ?g/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 56 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: DR4
Clonality: Monoclonal
Clone: 32A1380
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human