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Specifications
- Antibody type:Primary
- Antigen name:Desmin
- Clonality:Monoclonal
- Clone:D33
- Gene ID:1674
- Host:Mouse
- Isotype:IgG1
- Reactivity:Hamster
- Antigen symbol:DES
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:1 ml
- Western blot:Yes
- Antigen synonyms:CSM1|SCPNK|MFM1|CMD1I|intermediate filament protein|CSM2
- Storage buffer:Contains sodium azide
- Storage temperature:Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
- Immunogen:Full length native protein purified from human muscle.
- Tested applications:IHC-P
- Purification:Unpurified
- Cat. no.:89351-348
- Supplier No.:GTX17156
Specifications
About this item
Desmins are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Defects in Desmin are the cause of desmin-related cardio-skeletal myopathy (CSM) also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Desmin belongs to the intermediate filament family.
For IHC-P: Use at a dilution of 1:25-1:50 (ABC method). We suggest an incubation perios of 30 min at RT. For WB: Use at a dilution of 1:50-1:100. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Type: Primary
Antigen: DES
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Hamster