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Specifications
- Antibody type:Primary
- Antigen name:Proopiomelanocortin
- Clonality:Monoclonal
- Clone:B31.15
- Gene ID:5443
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:POMC
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:100 μg
- Antigen synonyms:OTTHUMP00000119991|adrenoCorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating|NPP|beta-LPH|lipotropin beta|hormone/ beta-endorphin|alpha-melanocyte-stimulating hormone|adrenocorticotropic hormone|lipotropin gamm|POC|beta-melanocyte-stimulating hormone|gamma-MSH|alpha-MSH|beta-endorphin|CLIP|LPH|Precursor of MSH|adrenoCorticotropin|POMC|proopiomelanocortin|gamma-LPH|OTTHUMP00000200964|Corticotropin-like intermediary peptide|ACTH
- Storage buffer:Phosphate buffered saline pH 7.4 containing 15mM sodium azide
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:1 mg/ml
- Immunogen:Full length native protein (purified) (Human).
- Tested applications:ICC/IF, IHC-Fr
- Purification:>95% by SDS-PAGE
- Cat. no.:89361-020
- Supplier No.:GTX21419
Specifications
About this item
Corticotropin (ACTH), synthesized by the anterior pituitary gland, stimulates the adrenal cortex. Human ACTH has a molecular weight of 4,541 and contains 39 amino acids . It has structural similarities to melanotropin (melanocyte-stimulating hormone; MSH). Human beta-melanotropin has 22 amino acid residues and a molecular weight of 2,661. Work on the structure of the ACTH gene by restriction enzyme techniques showed that 6 hormones are derived from one gene: ACTH, lipotropin, alpha-MSH, beta-MSH, endorphin, and one other. Thus, extensive amino acid differences between these hormones were not adequate evidence for their being distinct. ACTH and beta-lipotropin (beta-LPH) are derived from a large precursor peptide. Each of these hormones is known to include smaller peptides having distinct biologic activities: alpha-melanotropin (alpha-MSH) and corticotropin-like intermediate lobe peptide (CLIP) are formed from ACTH; gamma-LPH and beta-endorphin are peptide components of beta-LPH. Beta-MSH is contained within gamma-LPH. The precursor peptide was called proopiomelanocortin (POMC).
IF: Use at an assay dependant concentration. IHC-Fr: Use at an assay dependant concentration. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: POMC
Clonality: Monoclonal
Clone: B31.15
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human